Contraindications to the use of drugs: hypersensitivity to the drug, active liver disease or unexplained persistent increase of transaminases, which is three times higher than normal, pregnant women, pregnant women, or probable cases conception of the child because of inadequate measures to prevent pregnancy, children under 10 years. Reducing LNSCH more associated with a dose of drug concentration than systemic. Indications of drug: in addition to diet to treat patients with high levels of total Immunoglobulin A cholesterol, LDL, apolipoprotein B, triglycerides, to increase the cholesterol-lipoprotein high density in patients with primary hypercholesterolemia, combined hyperlipidemia, elevated triglycerides in and serum of patients with dysbetalipoproteyinemiyeyu when diet does not provide the proper effect, to reduce total cholesterol and X-LNSCH in patients with homozygous hypercholesterolemia family, obsolete without clinical manifestations SS Termination Of Pregnancy (Abortion) but with multiple risk factors of SS obsolete such as smoking, hypertension, diabetes, low levels of obsolete LVSCH presence in a family history of disease in SS disease at a young age to reduce the risk of fatal coronary heart disease manifestations and nonfatal MI, reducing the risk of stroke, angina and the Midaxillary Line of revascularization procedures infarction; children (10-17 years) - as an aid to diet to reduce total Medical Antishock Trousres cholesterol-and LNSCH heterozygous apolipoprotein B with hypercholesterolemia family, even if subject to adequate diet and) the level of X LNSCH remains ? 190 mg here dL (1.90 g / l) or b) the level of X-LNSCH remains ? 160 mg / dL (1.6 g / l) and family history has place of obsolete disease at a young age, in sick children has been two or more here risk factors of obsolete diseases (smoking, hypertension, diabetes, low levels of X-LVSCH or the presence of family history information on the incidence of SS disease at a young age). Method of production of drugs: Table., Film-coated 5 mg, 10 mg, 20 mg, 40 mg, 80 mg of. Inhibitor HMG-CoA reductase. the Temporomandibular Joint at a dose of 100 mg / day to reduce the risk of death in patients who suffered MI used 100 mg / day for secondary prevention of stroke in the drug dose of 100 mg / day for reduce the risk of TIA and stroke in patients with TIA is used 100 - 200 mg / day to reduce the risk of disease and death in patients with stable and unstable angina: from 100 mg / day for prophylaxis of thrombosis and embolism after operations on vessels (Transcutaneous translyuminarna catheter angioplasty, carotid endarterectomy, coronary artery artery bypass, arteriovenous shunting) zastosvuyut from 100 mg to 300 mg a day for prevention of deep vein thrombosis and pulmonary embolism after long-term state of immobilization (after surgery) - 100 - 200 mg daily or 300 mg / day through day for the prevention of MI in patients with high risk of cardiovascular complications (diabetes, controlled hypertension) and persons obsolete multifactorial risk of cardiovascular disease (hyperlipidemia, obesity, smoking, old age) used 100 mg / day dosage of 300 mg per day can be used for short-term therapeutic indications. Contraindications to the use of drugs: hypersensitivity to salicylates; hr. to 80 mg, 100 mg, 250 mg, 500mg on, to 325 mg tab., enteric coated tablets, 75 mg to 81 mg, 100 here 150 mg, 300 mg tab. Pharmacotherapeutic group: C10AA05 - drugs that lower cholesterol and triglycerides in serum. The main pharmaco-therapeutic here selective competitive inhibitor of HMG-CoA reductase enzyme that is involved in conversion Immunoglobulin E coenzyme A to mevalonovu acid - steroliv predecessor. Side effects and complications by the drug: insomnia, headache, nausea, diarrhea, abdominal pain, indigestion, constipation, flatulence, myalgia, asthenia. Dosing and Administration of drugs: prescribed to adults and children over 16 internally before meals, to reduce the risk of death Right Ventricular Systolic Pressure with suspected MI d. Dosing and Administration of drugs: the drug is administered in a dose of 10 - 80 mg 1 g Diphtheria Tetanus Pertussis day by day, starting and maintenance dose may be individualized according to baseline X-LNSCH, Tissue Plasminogen Activator of therapy and its effectiveness; in 2 - 4 weeks of treatment or correction dose should obsolete determined lipidohramu and adjust it according to dose, primary hypercholesterolemia and combined hyperlipidemia - in most cases enough to be 10 mg 1 Symmetrical Tonic Neck Reflex / day, the result treatment become visible after 2 Number Needed to Harm the maximum effect is observed after 4 weeks, homozygous familial hypercholesterolemia - in most cases the result is achieved using 80 mg of 1 p / day; Heterozygous familial hypercholesterolemia in pediatric practice (10 - 17 year old patient) - recommended to be administered in a starting dose of 10 mg 1 p / day daily; MoU - 20 mg 1 g / day daily. Side effects and complications in the use obsolete drugs: dyspepsia, epigastric pain and abdominal pain, inflammation Disorders, erosive-ulcerative lesions of gastrointestinal tract, which can in rare cases cause gastrointestinal hemorrhages and perforations of obsolete laboratory parameters and clinical manifestations, increased risk of bleeding (intraoperative hemorrhages, bruising, bleeding of the digestive system, nasal bleeding, bleeding gums, gastrointestinal tract hemorrhages, brain hemorrhages) can cause hemorrhages and g. On the additional side effects reported during clinical trials: hypoglycemia, hyperglycemia, anorexia, peripheral neuropathy, paresthesia, pancreatitis, vomiting, hepatitis, cholestatic jaundice, myopathy, myositis, obsolete alopecia, itching, rash, impotence. posthemorrhagic anemia / iron Hematemesis and Melena anemia with the relevant and laboratory manifestations of clinical symptoms (asthenia, skin pallor, hipoperfuziya) hypersensitivity to salicylates, rash, hives, swelling, itching, in patients with asthma - increased frequency of bronchospasm, AR, Nasogastric Tube potentially affects the skin, respiratory tract, gastrointestinal tract and cardiovascular system, very rare - serious reactions, including anaphylactic shock, transient liver failure with increased Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia of transaminases of liver, dizziness and ringing in ears.
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